… 6 h in hemodialysis patients to a 27 g/24-h continuous infusion in a patient with a short PT
half-… Predicted free steady-state piperacillin troughs on 4.5 g every 6 h are displayed in Fig. 1, …

… Simulated steady-state concentrations were 1.43-times, 95%CI = (1.27; 1.61), higher in …
We could further show that prolonged and continuous infusions might be necessary for MIC …

… population pharmacokinetic analysis of CI piperacillin/tazobactam… steady-state concentration
(Css) of increasing piperacillin/tazobactam regimens (from 2.25 to 18 g daily by continuous …

… Initial TDM (referred to as day1) was performed under steady-state conditions (> 4 halftimes;
… CL PIP in obese patients [33], we assessed and compared CrCL in the different BMI groups. …

… Simulations showed that continuous or extended infusion … administration to achieve appropriate
pharmacodynamic … important pharmacokinetic elements for piperacillin-tazobactam in an …

… of patients received extended-infusion piperacillin-tazobactam … as extended or continuous
infusions [36–38]. A PK study … may not be representative of steady-state estimations. Protein …

… reported with meropenem and piperacillin-tazobactam, with faster … Pharmacokinetics,
safety and tolerability of high-dose ceftobiprole medocaril administered as prolonged infusion …

… : Patients admitted to the urology ward who were treated with CI piperacillin–tazobactam or
… Average steady-state (C ss ) piperacillin–tazobactam and meropenem concentrations were …

… continuous infusion and intermittent infusion piperacillin/tazobactam or meropenem in critically
ill patients … intermittent infusion) in obese patients via Monte Carlo simulation (Table III). …

… exposure were performed, with a median (IQR) of 2 (1–2.5) assessments per patient. Median
(IQR) piperacillin and tazobactam free steady-state concentrations (fC ss ) were 54.6 mg/L (…